Select carcinogens, reproductive toxins, and chemicals with a high degree of acute toxicity are considered to be high-risk materials and are treated by Cal/OSHA as Particularly Hazardous Substances. Additional provisions for working with Particularly Hazardous Substances are described in Section 3.4.

Select Carcinogens

Carcinogens are chemicals or physical agents that cause cancer or tumor development, typically after repeated or chronic exposure. Their effects may only become evident after a long latency period and may cause no immediate harmful effects.

See the glossary for the Cal/OSHA definition of a Select Carcinogen.

See the General Use SOP for Carcinogens.

Reproductive Toxins

A chemical which affects reproductive capabilities. Possible effects include chromosomal damage (mutations), effects on fetuses (teratogenesis), adverse effects on sexual function and fertility in adult males and females, as well as adverse effects on the development of the offspring. Many reproductive toxins cause damage after repeated low-level exposures. Effects become evident after long latency periods.

See the General Use SOP for Reproductive Toxins.

Highly Acutely Toxic Substances

Categorized based on their LC50 or LD50 values, substances with a high degree of acute toxicity have the ability to cause adverse effects after a single exposure/dose or multiple exposures/doses within a 24 hour period. Many of these chemicals may also be characterized as toxic gases, Select Agent Toxins, corrosives, irritants, or sensitizers.

See the General Use SOP for Highly Toxic Chemicals.