Prions and Prion-like Proteins

Anyone working with prions, prion-like proteins or other Spongiform encephalopathies that may be present in brain tissue must call the Biosafety Manager, 725.1473. Slow viruses such as Kuru are included in this group. Prions and prion-like proteins (see Chapter 4 for a definition of prion-like proteins) are highly resistant to conventional decontamination, and laboratories are strongly encouraged to use only disposable equipment. Specific procedures for decontamination and disposal must be followed when working with prions and prion-like proteins. Contact Biosafety for further information, or visit the following sites for information on protocols:

• World Health Organization (WHO) Infection Control Guidelines
  https://www.who.int/csr/resources/publications/bse/WHO_CDS_CSR_APH_2000_3/en/
• Centers for Disease Control (CDC) Prion Diseases
  https://www.cdc.gov/ncidod/dvrd/prions/index.htm
• Biosafety in Microbiology and Biomedical Laboratories (BMBL)
  https://www.cdc.gov/biosafety/publications/bmbl5/BMBL5_sect_VIII_h.pdf